Publications from the Thomas Poulsen lab

Click the graphical abstract to read the article.

Preprints

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Find the new paper from Esben, Florian and collaborators from the Department of Biomedicine describing detection of the oxidation state of N-terminal cysteines in XXX now.

E. B. Svenningsen, F. Demir, F. E. H. Kromm, A. H. F. Rahimic, D. Olagnier, M. M. Rinschen, T. B. Poulsen, “Chemoproteomic mapping of the N-terminal cysteinome”, ChemRxiv., 2024, DOI: 10.26434/chemrxiv-2024-4w549

Peer-reviewed publications

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Read about the preclinical studies of the LaKe ester, which allows for simultaneous administration of lactate and a beta-hydroxybutyrate precursor in Journal of Agricultural and Food Chemistry now!

68. R. N. Ottosen, J. M. Seefeldt, J. Hansen, R. Nielsen, N. Møller, M. Johannsen, T. B. Poulsen, “Preparation and Preclinical Characterization of a Simple Ester for Dual Exogenous Supply of Lactate and Beta-hydroxybutyrate”, J. Agric. Food Chem., 2024, 72, 19883–19890, DOI: 10.1021/acs.jafc.4c04849

67. N. Kurmasheva, A. Said, B. Wong, P. Kinderman, X. Han, A. H. F. Rahimic, A. Kress, M. E. Carter-Timofte, E. Holm, D. van der Horst, C. F. Kollmann, Z. Liu, C. Wang, H.-D. Hoang, E. Kovalenko, M. Chrysopoulou, K. S. Twayana, R. N. Ottosen, E. B.

67. N. Kurmasheva, A. Said, B. Wong, P. Kinderman, X. Han, A. H. F. Rahimic, A. Kress, M. E. Carter-Timofte, E. Holm, D. van der Horst, C. F. Kollmann, Z. Liu, C. Wang, H.-D. Hoang, E. Kovalenko, M. Chrysopoulou, K. S. Twayana, R. N. Ottosen, E. B. Svenningsen, F. Begnini, A. E. Kiib, F. E. H. Kromm, H. J. Weiss, D. Di Carlo, M. Muscolini, M. Higgins, M. van der Heijden, A. Bardoul, T. Tong, A. Ozsvar, W.-H. Hou, V. R. Schack, C. K. Holm, Y. Zheng, M. Ruzek, J. Kalucka, L. de la Vega, W. A. M. Elgaher, A. R. Korshoej, R. Lin, J. Hiscott, T. B. Poulsen, L. A. O’Neill, D. G. Roy, M. M. Rinschen, N. van Montfoort, J.-S. Diallo, H. F. Farin, T. Alain, D. Olagnier, "Octyl itaconate enhances VSVΔ51 oncolytic virotherapy by multitarget inhibition of antiviral and inflammatory pathways", Nat. Commun., 2024, 15, 4096, DOI: 10.1038/s41467-024-48422-x

66. P. Waser, J. Faghtmann, M. Gil-Ordóñez, A. Kristensen, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “Enantioselective Synthesis of α-Quaternary Isochromanes by Oxidative Aminocatalysis and Gold Catalysis”, Chem. Eur. J. , 2024, 30 , e2

66. P. Waser, J. Faghtmann, M. Gil-Ordóñez, A. Kristensen, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “Enantioselective Synthesis of α-Quaternary Isochromanes by Oxidative Aminocatalysis and Gold Catalysis”, Chem. Eur. J., 2024, 30, e202401354, DOI: 10.1002/chem.202401354

65. J. Faghtmann, M. Eugui, J. N. Lamhauge, S. S. P. Andresen, A. R. Østergaard, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “An Enantioselective Aminocatalytic Cascade Reaction Affording Bioactive Hexahydroazulene Scaffolds”, Chem. Eur. J.

65. J. Faghtmann, M. Eugui, J. N. Lamhauge, S. S. P. Andresen, A. R. Østergaard, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, “An Enantioselective Aminocatalytic Cascade Reaction Affording Bioactive Hexahydroazulene Scaffolds”, Chem. Eur. J., 2024, 30, e202401156, DOI: 10.1002/chem.202401156

Check out ChemBioChem for the newest findings about the biological activity of Routiennocin made possible by Søren's synthesis of its enantiomer.

64. S. L. B. Møller, M. H. Rasmussen, J. Li, E. B. Svenningsen, G. J. Wørmer, T. Tørring, T. B. Poulsen, “The Biological Activities of Polyether Ionophore Antibiotic Routiennocin is Independent of Absolute Stereochemistry”, ChemBioChem, 2024, 25, e202400013, DOI: 10.1002/cbic.202400013

63. M. Busk, P. P. Eggertsen, J. Overgaard, M. R. Horsman, T. Tørring, K. M. Jacobsen, T. B. Poulsen, “ In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-43547”, Anticancer Res. , 2023 , 43 , 5319-5329, DOI: 10.

63. M. Busk, P. P. Eggertsen, J. Overgaard, M. R. Horsman, T. Tørring, K. M. Jacobsen, T. B. Poulsen, “In Vitro Characterization of the Bacteria-derived Hypoxia-selective Cytotoxin BE-43547”, Anticancer Res., 2023, 43, 5319-5329, DOI: 10.21873/anticanres.16735

62. F. H. Waqas, M. Shehata, W. A. M. Elgaher, A. Lacour, N. Kurmasheva, F. Begnini, A. E. Kiib, J. Dahlmann, C. Chen, A. Pavlou, T. B. Poulsen, S. Merkert, U. Martin, R. Olmer, D. Olagnier, A. K. H. Hirsch, S. Pleschka, F. Pessler, “NRF2 activators

62. F. H. Waqas, M. Shehata, W. A. M. Elgaher, A. Lacour, N. Kurmasheva, F. Begnini, A. E. Kiib, J. Dahlmann, C. Chen, A. Pavlou, T. B. Poulsen, S. Merkert, U. Martin, R. Olmer, D. Olagnier, A. K. H. Hirsch, S. Pleschka, F. Pessler, “NRF2 activators inhibit influenza A virus replication by interfering with nucleo-cytoplasmic export of viral RNPs in an NRF2-independent manner”, PLOS Pathog., 2023, 19, e1011506, DOI: 10.1371/journal.ppat.1011506

Malene's work on how polyether ionophores target persister cells and biofilms can be found in the latest issue of Microbiology Spectrum.

61. M. Wollesen, K. Mikkelsen, M. S. Tvilum, M. Vestergaard, M. Wang, R. L. Meyer, H. Ingmer, T. B. Poulsen, T. Tørring, “Polyether Ionophore Antibiotics Target Drug-Resistant Clinical Isolates, Persister Cells, and Biofilms”, Microbiol. Spectr., 2023, 11, e00625-23, DOI: 10.1128/spectrum.00625-23

First seen on BioRxiv: doi.org/10.1101/2023.02.13.528344

Read about Marija, Gustav, Cecilie and Sofie's work on oxSTEF reagents, a new tool for disulfide rebridging, in Bioconjugate Chemistry.

60. M. Nisavic, G. J. Wørmer, C. S. Nielsen, S. M. Jeppesen, J. Palmfeldt, T. B. Poulsen, “oxSTEF Reagents Are Tunable and Versatile Electrophiles for Selective Disulfide-Rebridging of Native Proteins”, Bioconjugate Chem., 2023, 34, 994-1003, DOI: 10.1021/acs.bioconjchem.3c00005

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2022-7pkxq

Alejandro and Anders' work on α-Lactam electrophiles in a biological context has now been published in Angewandte Chemie.

59. A. Mahía, A. E. Kiib, M. Nisavic, E. B. Svenningsen, J. Palmfeldt, T. B. Poulsen, “α-Lactam Electrophiles for Covalent Chemical Biology”, Angew. Chem. Int. Ed., 2023, 62, e202304142, DOI: 10.1002/anie.202304142

First seen on ChemRxiv: doi.org/10.26434/chemrxiv-2022-p4wtd

Esbens and Rasmus' work on the chemistry and biology of the funky electrophile MT-21 has been published in RSC Chemical Biology

58. E. B. Svenningsen, R. N. Ottosen, K. H. Jørgensen, M. Nisavic, C. K. Larsen, B. K. Hansen, Y. Wang, K. Lindorff-Larsen, T. Tørring, S. M. Hacker, J. Palmfeldt, T. B. Poulsen, "The Covalent Reactivity of Functionalized 5-Hydroxy-Butyrolactams Is the Basis for Targeting of Fatty Acid Binding Protein 5 (FABP5) by the Neurotrophic Agent MT-21", RSC Chem. Biol., 2022, 3, 1216-1229, DOI: 10.1039/D2CB00161F

57. F. D. Andersen, K. D. Pedersen, D. Wilkens Juhl, T. Mygind, P. Chopin, E. B. Svenningsen, T. B. Poulsen, M. Braad Lund, A. Schramm, C. H. Gotfredsen, T. Tørring, "Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity", J.

57. F. D. Andersen, K. D. Pedersen, D. Wilkens Juhl, T. Mygind, P. Chopin, E. B. Svenningsen, T. B. Poulsen, M. Braad Lund, A. Schramm, C. H. Gotfredsen, T. Tørring, "Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity", J. Nat. Prod., 2022, 85, 1514-1521, DOI: 10.1021/acs.jnatprod.2c00065

56. L. Casares, R. Moreno, K. X. Ali, M. Higgins, S. Dayalan Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, A. Minassi, T. Honda, T. B. Poulsen, C. Wiel, V. I. Sayin, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega, "The Synthetic Trit

56. L. Casares, R. Moreno, K. X. Ali, M. Higgins, S. Dayalan Naidu, G. Neill, L. Cassin, A. E. Kiib, E. B. Svenningsen, A. Minassi, T. Honda, T. B. Poulsen, C. Wiel, V. I. Sayin, A. T. Dinkova-Kostova, D. Olagnier, L. de la Vega, "The Synthetic Triterpenoids CDDO-TFEA and CDDO-Me, but Not CDDO, Promote Nuclear Exclusion of BACH1 Impairing Its Activity", Redox Biol., 2022, 51, 102291, DOI: 10.1016/j.redox.2022.102291

Read the 'behind the scenes' of Gustav's work on the [4.3.0] Piperidine Alkaloids in Synlett

55. G. J. Wørmer, T. B. Poulsen, "The [4.3.0] Piperidine Alkaloids: Architectures, Biology, Biosyntheses and the Complete Details of the Asymmetric Syntheses of Streptazone A and Abikoviromycin", Synlett, 2022, 33, 637-654, DOI: 10.1055/a-1688-0826

Marie's master thesis work on normoxia selectivity of ferroptosis inducers on the front cover of ChemBioChem

54. M. B. Cordon*, K. M. Jacobsen*, C. S. Nielsen, P. Hjerrild, T. B. Poulsen, "Forward Chemical Genetic Screen for Oxygen‐Dependent Cytotoxins Uncovers New Covalent Fragments That Target GPX4", ChemBioChem, 2022, 23, e202100253, DOI: 10.1002/cbic.202100253

*Shared first author

Featured in “Chemical Proteomics and Metabolomics” special edition. Chosen as “Very Important Paper” (VIP).

Featured as front cover

Han and Rasmus' neatly designed total synthesis of Vermiculine, resulting in 18 analogs, has just been accepted in Angewandte

53. H. Liu, R. N. Ottosen, K. M. Jennet, E. B. Svenningsen, T. F. Kristensen, M. Biltoft, M. R. Jakobsen, T. B. Poulsen, "Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the CGAS‐STING Pathway", Angew. Chem. Int. Ed., 2021, 60, 18734–18741, DOI: 10.1002/anie.202105793

52. Y. Liu, J. A. Izzo, D. McLeod, S. Ričko, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, "Organocatalytic Asymmetric Multicomponent Cascade Reaction for the Synthesis of Contiguously Substituted Tetrahydronaphthols", J. Am. Chem. Soc. , 202

52. Y. Liu, J. A. Izzo, D. McLeod, S. Ričko, E. B. Svenningsen, T. B. Poulsen, K. A. Jørgensen, "Organocatalytic Asymmetric Multicomponent Cascade Reaction for the Synthesis of Contiguously Substituted Tetrahydronaphthols", J. Am. Chem. Soc., 2021, 143, 8208–8220, DOI: 10.1021/jacs.1c03923

51. L. Dichmann, M. Bregnhøj, H. Liu, M. Westberg, T. B. Poulsen, M. Etzerodt, P. R. Ogilby, "Photophysics of a Protein-Bound Derivative of Malachite Green That Sensitizes the Production of Singlet Oxygen", Photochem. Photobiol. Sci. , 2021 , 20

51. L. Dichmann, M. Bregnhøj, H. Liu, M. Westberg, T. B. Poulsen, M. Etzerodt, P. R. Ogilby, "Photophysics of a Protein-Bound Derivative of Malachite Green That Sensitizes the Production of Singlet Oxygen", Photochem. Photobiol. Sci., 2021, 20, 435–449, DOI: 10.1007/s43630-021-00032-y

Read Thomas' contribution to the special issue of Acc. Chem. Res. on Total Synthesis of Natural Products

50. T. B. Poulsen, "Total Synthesis of Natural Products Containing Enamine or Enol Ether Derivatives", Acc. Chem. Res., 2021, 54, 1830–1842, DOI: 10.1021/acs.accounts.0c00851
Contribution to Acc. Chem. Res. special issue on “Total Synthesis of Natural Products”

Featured
Gustav's work on the total synthesis of Streptazones and Abikoviromycin is featured on the front cover of Angewandte

49. G. J. Wørmer, N. L. Villadsen, P. Nørby, T. B. Poulsen, "Concise Asymmetric Syntheses of Streptazone A and Abikoviromycin", Angew. Chem. Int. Ed., 2021, 60, 10521–10525, DOI: 10.1002/anie.202101439
Featured as front cover

First seen on ChemRxiv: doi.org/10.26434/chemrxiv.13293356.v1

Our work on expanding the capabilities of the polyether ionophores has been published in Nature Chemistry

48. S. Lin, H. Liu, E. B. Svenningsen, M. Wollesen, K. M. Jacobsen, F. D. Andersen, J. Moyano-Villameriel, C. N. Pedersen, P. Nørby, T. Tørring, T. B. Poulsen, "Expanding the Antibacterial Selectivity of Polyether Ionophore Antibiotics through Diversity-Focused Semisynthesis", Nat. Chem., 2021, 13, 47–55, DOI: 10.1038/s41557-020-00601-1

First seen on ChemRxiv: doi.org/10.26434/chemrxiv.8299715.v1

Read our paper on the discovery of the polyether ionophore X-206 as a potent inhibitor of SARS-CoV-2 infection in vitro

47. E. B. Svenningsen, J. Thyrsted, J. Blay-Cadanet, H. Liu, S. Lin, J. Moyano-Villameriel, D. Olagnier, M. Idorn, S. R. Paludan, C. K. Holm, T. B. Poulsen, "Ionophore Antibiotic X-206 Is a Potent Inhibitor of SARS-CoV-2 Infection in Vitro", Antiviral Res., 2021, 185, 104988, DOI: 10.1016/j.antiviral.2020.104988

First seen on BioRxiv: doi.org/10.1101/2020.06.14.149153

46. D. Olagnier, E. Farahani, J. Thyrsted, J. Blay-Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jørgensen, M. Thomsen, L. S. Reinert, M. Lappe, H.-D. Hoang, V. H. Gilchrist, A. L. Hansen, R. Otto

46. D. Olagnier, E. Farahani, J. Thyrsted, J. Blay-Cadanet, A. Herengt, M. Idorn, A. Hait, B. Hernaez, A. Knudsen, M. B. Iversen, M. Schilling, S. E. Jørgensen, M. Thomsen, L. S. Reinert, M. Lappe, H.-D. Hoang, V. H. Gilchrist, A. L. Hansen, R. Ottosen, C. G. Nielsen, C. Møller, D. van der Horst, S. Peri, S. Balachandran, J. Huang, M. Jakobsen, E. B. Svenningsen, T. B. Poulsen, L. Bartsch, A. L. Thielke, Y. Luo, T. Alain, J. Rehwinkel, A. Alcamí, J. Hiscott, T. Mogensen, S. R. Paludan, C. K. Holm, "SARS-CoV2-Mediated Suppression of NRF2-Signaling Reveals Potent Antiviral and Anti-Inflammatory Activity of 4-Octyl-Itaconate and Dimethyl Fumarate", Nat. Commun., 2020, 11, 4938, DOI: 10.1038/s41467-020-18764-3

First seen on BioRxiv: doi.org/10.1101/2020.07.16.206458

Our review on dehydrations is featured on the cover of Natural Product Reports

45. P. Hjerrild, T. Tørring, T. B. Poulsen, "Dehydration Reactions in Polyfunctional Natural Products", Nat. Prod. Rep., 2020, 37, 1043–1064, DOI: 10.1039/D0NP00009D
Featured as front cover

Final publication of our work on the Phenomycin peptide

44. B. K. Hansen, C. K. Larsen, J. T. Nielsen, E. B. Svenningsen, L. B. Van, K. M. Jacobsen, M. Bjerring, R. K. Flygaard, L. B. Jenner, L. N. Nejsum, D. E. Brodersen, F. A. A. Mulder, T. Tørring, T. B. Poulsen "Structure and Function of the Bacterial Protein Toxin Phenomycin", Structure, 2020, 28, 528-539.e9, DOI: 10.1016/j.str.2020.03.003

First seen on BioRxiv: doi.org/10.1101/847772

Collaboratory paper with the Weidner Lab on the analysis of the interaction of Lasalocid acid with membranes

43. T. W. Golbek, L. Schmüser, M. H. Rasmussen, T. B. Poulsen, T. Weidner, "Lasalocid Acid Antibiotic at a Membrane Surface Probed by Sum Frequency Generation Spectroscopy", Langmuir, 2020, 36, 3184–3192, DOI: 10.1021/acs.langmuir.9b03752

42. F. S. Bjørnskov, T. B. Poulsen, "On the Origin of the Blind Chicken Molecule", Nat. Chem. , 2020 , 12 , 2–3, DOI: 10.1038/s41557-019-0390-y

42. F. S. Bjørnskov, T. B. Poulsen, "On the Origin of the Blind Chicken Molecule", Nat. Chem., 2020, 12, 2–3, DOI: 10.1038/s41557-019-0390-y

Read our study of a cyclopropene covalently targeting GSTO1 in cells in Angewandte Chemie

41. G. J. Wørmer, B. K. Hansen, J. Palmfeldt, T. B. Poulsen, "A Cyclopropene Electrophile That Targets Glutathione S‐Transferase Omega‐1 in Cells", Angew. Chem. Int. Ed., 2019, 58, 11918–11922, DOI: 10.1002/anie.201907520

Paper describing our work with setting up Cell Painting is just published

40. E. B. Svenningsen, T. B. Poulsen, "Establishing Cell Painting in a Smaller Chemical Biology Lab – A Report from the Frontier", Bioorg. Med. Chem., 2019, 27, 2609–2615, DOI: 10.1016/j.bmc.2019.03.052

Mini review in Angewandte Chemie looking at ionophores

39. H. Liu, S. Lin, K. M. Jacobsen, T. B. Poulsen, "Chemical Syntheses and Chemical Biology of Carboxyl Polyether Ionophores: Recent Highlights", Angew. Chem. Int. Ed., 2019, 58, 13630–13642, DOI: 10.1002/anie.201812982

Paper in Angewandte Chemie describing STEFs: Semi-oxamide vinylogous thioester nucleophilic warheads

38. B. K. Hansen, C. J. Loveridge, S. Thyssen, G. J. Wørmer, A. D. Nielsen, J. Palmfeldt, M. Johannsen, T. B. Poulsen, "STEFs: Activated Vinylogous Protein-Reactive Electrophiles", Angew. Chem. Int. Ed., 2019, 58, 3533–3537, DOI: 10.1002/anie.201814073

37. D. Olagnier, A. M. Brandtoft, C. Gunderstofte, N. L. Villadsen, C. Krapp, A. L. Thielke, A. Laustsen, S. Peri, A. L. Hansen, L. Bonefeld, J. Thyrsted, V. Bruun, M. B. Iversen, L. Lin, V. M. Artegoitia, C. Su, L. Yang, R. Lin, S. Balachandran, Y.

37. D. Olagnier, A. M. Brandtoft, C. Gunderstofte, N. L. Villadsen, C. Krapp, A. L. Thielke, A. Laustsen, S. Peri, A. L. Hansen, L. Bonefeld, J. Thyrsted, V. Bruun, M. B. Iversen, L. Lin, V. M. Artegoitia, C. Su, L. Yang, R. Lin, S. Balachandran, Y. Luo, M. Nyegaard, B. Marrero, R. Goldbach-Mansky, M. Motwani, D. G. Ryan, K. A. Fitzgerald, L. A. O’Neill, A. K. Hollensen, C. K. Damgaard, F. v. de Paoli, H. C. Bertram, M. R. Jakobsen, T. B. Poulsen, C. K. Holm, "Nrf2 Negatively Regulates STING Indicating a Link between Antiviral Sensing and Metabolic Reprogramming", Nat. Commun., 2018, 9, 3506, DOI: 10.1038/s41467-018-05861-7

36. N. Hammer, J. D. Erickson, V. H. Lauridsen, J. B. Jakobsen, B. K. Hansen, K. M. Jacobsen, T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric [4+2]‐Cycloadditions Using Tropolones: Developments, Scope, Transformations, and Bioactivity", Angew

36. N. Hammer, J. D. Erickson, V. H. Lauridsen, J. B. Jakobsen, B. K. Hansen, K. M. Jacobsen, T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric [4+2]‐Cycloadditions Using Tropolones: Developments, Scope, Transformations, and Bioactivity", Angew. Chem. Int. Ed., 2018, 57, 13216–13220, DOI: 10.1002/anie.201808221

New paper in Cell Chemical Biology - Investigating the mode of action of APD-CLD's

35. K. M. Jacobsen, N. L. Villadsen, T. Tørring, C. B. Nielsen, T. Salomón, M. M. Nielsen, M. Tsakos, C. Sibbersen, C. Scavenius, R. Nielsen, E. I. Christensen, P. F. Guerra, P. Bross, J. S. Pedersen, J. J. Enghild, M. Johannsen, J. Frøkiær, J. Overgaard, M. R. Horsman, M. Busk, T. B. Poulsen, "APD-Containing Cyclolipodepsipeptides Target Mitochondrial Function in Hypoxic Cancer Cells", Cell Chem. Biol., 2018, 25, 1337-1349.e12, DOI: 10.1016/j.chembiol.2018.07.010

New paper in Angewandte Chemie - Making heteroatom-functionalized quinones

34. W. Yu, P. Hjerrild, K.M. Jacobsen, H. N. Tobiesen, L. Clemmensen, T. B. Poulsen, "A Catalytic Oxidative Quinone Heterofunctionalization Method - Synthesis of Strongylophorine-26", Angew. Chem. Int. Ed. 2018, 57, 9805-9809, DOI: 10.1002/anie.201805580

New paper in JOC - Teasing out the relationsship between the stendomycin and pantomycin natural products

33. N. L. Villadsen, B. K. Hansen, E. B. Svenningsen, K. H. Jørgensen, T. Tørring, T. B. Poulsen, "Stendomycin and Pantomycin are Identical Natural Products – Preparation of a Functionalized Bioactive Analog", J. Org. Chem. 2018, 83, 7303–7308, DOI: 10.1021/acs.joc.8b00553

32. T. Salomón, C. Sibbersen, J. Hansen, D. Britz, M. V. Svart, T. S. Voss, N. Møller, N. Gregersen, K. A. Jørgensen, J. Palmfeldt, T. B. Poulsen, M. Johannsen, ”Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Di

32. T. Salomón, C. Sibbersen, J. Hansen, D. Britz, M. V. Svart, T. S. Voss, N. Møller, N. Gregersen, K. A. Jørgensen, J. Palmfeldt, T. B. Poulsen, M. Johannsen, ”Ketone Body Acetoacetate Buffers Methylglyoxal via a Non-enzymatic Conversion during Diabetic and Dietary Ketosis”, Cell Chem. Biol. 2017, 24, 935-943, DOI: 10.1016/j.chembiol.2017.07.012
Featured on issue cover

31. E. F. Holmquist, U. B. Keiding, R. Kold-Christensen, T. Salomón, K. A. Jørgensen , P. Kristensen, T. B. Poulsen, M. Johannsen, "ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism" Anal. Chem. 2017 ,

31. E. F. Holmquist, U. B. Keiding, R. Kold-Christensen, T. Salomón, K. A. Jørgensen , P. Kristensen, T. B. Poulsen, M. Johannsen, "ReactELISA: Monitoring a Carbon Nucleophilic Metabolite by ELISA—a Study of Lipid Metabolism" Anal. Chem. 2017, 89, 5066-5071, DOI: 10.1021/acs.analchem.7b00507

30. N. L. Villadsen, K. M. Jacobsen, U. B. Keiding, E. T. Weibel, B. Christiansen, T. Vosegaard, M. Bjerring, F. Jensen, M. Johannsen, T. Tørring, T. B. Poulsen, "Synthesis of ent -BE-43547A 1 reveals a potent hypoxia-selective anticancer agent an

30. N. L. Villadsen, K. M. Jacobsen, U. B. Keiding, E. T. Weibel, B. Christiansen, T. Vosegaard, M. Bjerring, F. Jensen, M. Johannsen, T. Tørring, T. B. Poulsen, "Synthesis of ent-BE-43547A1 reveals a potent hypoxia-selective anticancer agent and uncovers the biosynthetic origin of the APD-CLD natural products" Nat. Chem. 2017, 9, 264-272, DOI: 10.1038/nchem.2657

29. H. Feinberg, N. D. S. Rambaruth, S. A. F. Jégouzo, K. M. Jacobsen, R. Djurhuus, T. B. Poulsen, W. I. Weis, M. E. Taylor, K. Drickamer, "Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Do

29. H. Feinberg, N. D. S. Rambaruth, S. A. F. Jégouzo, K. M. Jacobsen, R. Djurhuus, T. B. Poulsen, W. I. Weis, M. E. Taylor, K. Drickamer,
"Binding Sites for Acylated Trehalose Analogs of Glycolipid Ligands on an Extended Carbohydrate Recognition Domain of the Macrophage Receptor Mincle" J. Biol. Chem. 2016, 291, 21222-21333, DOI: 10.1074/jbc.M116.749515

28. M. Tsakos, K. M. Jacobsen, W. Yu, N. L. Villadsen, T. B. Poulsen, "The Rakicidin Family of Anticancer Natural Products – Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins" Synlett. 2016 , 27, 1898-1906, DOI: 10.1055/

28. M. Tsakos, K. M. Jacobsen, W. Yu, N. L. Villadsen, T. B. Poulsen,
"The Rakicidin Family of Anticancer Natural Products – Synthetic Strategies towards a New Class of Hypoxia-Selective Cytotoxins" Synlett. 2016, 27, 1898-1906, DOI: 10.1055/s-0035-1561465

27. W. Yu, P. Hjerrild, J. Overgaard, T. B. Poulsen, "A Concise Route to the Strongylophorines" Angew. Chem. Int. Ed. 2016 , 55, 8294-8298, DOI: 10.1002/anie.201602476

27. W. Yu, P. Hjerrild, J. Overgaard, T. B. Poulsen, "A Concise Route to the Strongylophorines" Angew. Chem. Int. Ed. 2016, 55, 8294-8298, DOI: 10.1002/anie.201602476

26. M. Tsakos, L. L. Clement, E. S. Schaffert, F. N. Olsen, S. Rupiani, R. Djurhuus, W. Yu, K. M. Jacobsen, N. L. Villadsen, T. B. Poulsen, "Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue",

26. M. Tsakos, L. L. Clement, E. S. Schaffert, F. N. Olsen, S. Rupiani, R. Djurhuus, W. Yu, K. M. Jacobsen, N. L. Villadsen, T. B. Poulsen, "Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue", Angew. Chem. Int. Ed. 2016, 55, 1030-1035, DOI: 10.1002/anie.201509926

25. F. N. Olsen, M. Tsakos, T. B. Poulsen, "Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks", Synlett , 2015 , eFirst, DOI: 10.1055/s-0035-1560537

25. F. N. Olsen, M. Tsakos, T. B. Poulsen, "Npys-Mediated Elimination Reactions of Alcohols and Thiols: A Facile Route to Dehydroalanine and Dehydrobutyrine Building Blocks", Synlett, 2015, eFirst, DOI: 10.1055/s-0035-1560537

24. M. Gruca, W. Yu, P. Amoateng, M. A. Nielsen, T.B. Poulsen, H. Balslev, "Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart" J. Ethnopharmacol. 2015 , 175 , 356-369, DOI: 10.1016/j.jep.2015.09.010

24. M. Gruca, W. Yu, P. Amoateng, M. A. Nielsen, T.B. Poulsen, H. Balslev, "Ethnomedicinal survey and in vitro anti-plasmodial activity of the palm Borassus aethiopum Mart" J. Ethnopharmacol. 2015, 175, 356-369, DOI: 10.1016/j.jep.2015.09.010

23. L. L. Clement, M. Tsakos, E. S. Schaffert, C. Scavenius, J. J. Enghild, T. B. Poulsen, "The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile – development of a general synthetic strategy" Chem. Commun. 2015

23. L. L. Clement, M. Tsakos, E. S. Schaffert, C. Scavenius, J. J. Enghild, T. B. Poulsen, "The amido-pentadienoate-functionality of the rakicidins is a thiol reactive electrophile – development of a general synthetic strategy" Chem. Commun. 2015, 51, 12427-12430, DOI: 10.1039/C5CC04500B

22. M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen, T. B. Poulsen, "Ester Coupling Reactions - An Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products", Nat. Prod. Rep. 2015 , 32 , 605-632, DOI: 10.1039/C4NP001

22. M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen, T. B. Poulsen, "Ester Coupling Reactions - An Enduring Challenge in the Chemical Synthesis of Bioactive Natural Products", Nat. Prod. Rep. 2015, 32, 605-632, DOI: 10.1039/C4NP00106K

21. K. M. Jacobsen, U. B. Keiding, L. L. Clement, E. S. Schaffert, N. D. S. Rambaruth, M. Johannsen, K. Drickamer, T. B. Poulsen, "The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Re

21. K. M. Jacobsen, U. B. Keiding, L. L. Clement, E. S. Schaffert, N. D. S. Rambaruth, M. Johannsen, K. Drickamer, T. B. Poulsen, "The Natural Product Brartemicin is a High Affinity Ligand for the Carbohydrate-Recognition Domain of the Macrophage Receptor Mincle", Med. Chem. Commun. 2015, 6, 647-652, DOI: 10.1039/C4MD00512K

20. T. B. Poulsen, "A Concise Route to the Macrocyclic Core of the Rakicidins", Chem. Commun. 2011 , 47 , 12837-12839, DOI: 10.1039/C1CC15829E

20. T. B. Poulsen, "A Concise Route to the Macrocyclic Core of the Rakicidins", Chem. Commun. 2011, 47, 12837-12839, DOI: 10.1039/C1CC15829E

Post Doc, Harvard University, MD Shair Laboratory

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19. A. W. G. Burgett, T. B. Poulsen, K. Wangkanont, D. R. Anderson, C. Kikuchi, K. Shimada, S. Okubo, K. C. Fortner, Y. Mimaki, M. Kuroda, J. P. Murphy, D. J. Schwalb, E. C. Petrella, I. Cornella-Taracido, M. Schirle, J. A. Tallarico, M. D. Shair, "Natural Products Reveal Cancer Cell Dependence on Oxysterol-Binding Proteins", Nat. Chem. Biol. 2011, 7, 639-647

Post Doc, Aarhus University, Karl Anker Jørgensen laboratory

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18. G. Dickmeiss, V. De Sio, J. Udmark, T. B. Poulsen, V. Marcos, K. A. Jørgensen, "Organocatalytic Asymmetric Desymmetrization-Fragmentation of Cyclic Ketones" Angew. Chem. Int. Ed. 2009, 48, 6650-6653

17. D. G. Alberg, T. B. Poulsen, S. Bertelsen, K. L. Christensen, R. D. Birkler, M. Johannsen, K. A. Jørgensen, "Organocatalysis with Endogenous Compounds: Towards Novel Non-enzymatic Reactions" Bioorg. Med. Chem. Lett. 2009, 19, 3888-3891

PhD, Aarhus University, Karl Anker Jørgensen laboratory

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16. C. B. Madsen, L. B. Madsen, S. S. Viftrup, M. P. Johansson, T. B. Poulsen, L. Holmegaard, V. Kumarappan, K. A. Jørgensen, H. Stapelfeldt, "A Combined Experimental and Theoretical Study on Realizing and Using Laser Controlled Torsion of Molecules" J. Chem. Phys. 2009, 130, 234310

15. C. B. Madsen, L. B. Madsen, S. S. Viftrup, M. P. Johansson, T. B. Poulsen, L. Holmegaard, V. Kumarappan, K. A. Jørgensen, H. Stapelfeldt, "Manipulating the Torsion of Molecules by Strong Laser Pulses" Phys. Rev. Lett. 2009, 102, 073007

14. T. B. Poulsen, G. Dickmeiss, J. Overgaard, K. A. Jørgensen, "Organocatalytic Asymmetric Synthesis of Versatile gamma-Lactams" Angew. Chem. Int. Ed. 2008, 47, 4687-4690

13. T. B. Poulsen, K. A. Jørgensen, "Catalytic Asymmetric Friedel-Crafts Alkylation Reactions – Copper Showed the Way" Chem. Rev. 2008, 108, 2903-2915

12. S. Santoro, T. B. Poulsen, K. A. Jørgensen, "Enantioselective Organocatalytic Substitution of αlfa-Cyanoacetates on Imidoyl Chlorides – Synthesis of Optically Active Ketimines" Chem. Commun. 2007, 5155-5157

11. J. López-Cantarero, M. Belén Cid, T. B. Poulsen, M. Bella, J. L. G. Ruano, K. A. Jørgensen, "Intriguing Behaviour of Cinchona Alkaloids in the Enantioselective Organocatalytic Hydroxyamination of alfa-Substututed-alfa-Cyanoacetates" J. Org. Chem. 2007, 72, 7062-7065

10. M. Bell, T. B. Poulsen, K. A. Jørgensen, "Organocatalytic Enantioselective Nucleophilic Vinylic Substitution by alfa-Substituted-alfa-Cyanoacetates under Phase-Transfer Conditions" J. Org. Chem. 2007, 72, 3053-3056

9. T. B. Poulsen, L. Bernardi, J. Alemán, J. Overgaard, K. A. Jørgensen, "Organocatalytic Asymmetric alfa-Alkynylation of Cyclic beta-Ketoesters" J. Am. Chem. Soc. 2007, 129, 441-449

8. T. B. Poulsen, L. Bernardi, M. Bell, K. A. Jørgensen, "Organocatalytic Enantioselective Nucleophilic Vinylic Substitution" Angew. Chem. Int. Ed. 2006, 45, 6551-6554

7. T. B. Poulsen, M. Bell, K. A. Jørgensen, "Organocatalytic Asymmetric Allylic Carbon-Carbon Bond Formation" Org. Biomol. Chem. 2006, 4, 63-70 (Selected for Issue Cover)

6. T. B. Poulsen, C. Alemparte, K. A. Jørgensen, "Enantioselective Organocatalytic Allylic Amination" J. Am. Chem. Soc. 2005, 127i, 11614-11615

5. W. Zhuang, T. B. Poulsen, K. A. Jørgensen, "A versatile catalyst for asymmetric reactions of carbonyl groups working purely by activation through hydrogen bonding: Mukaiyama-aldol, hetero Diels-Alder and Friedel-Crafts reactions" Org. Biomol. Chem. 2005, 3, 3284-3289

4. M. Marigo, J. Franzén, T. B. Poulsen, W. Zhuang, K. A. Jørgensen, "Asymmetric Organocatalytic Epoxidation of alfa,beta-Unsaturated Aldehydes with Hydrogen Peroxide" J. Am. Chem. Soc. 2005, 127, 6964-6965

3. T. B. Poulsen, C. Alemparte, S. Saaby, M. Bella, K. A. Jørgensen, "Direct Organocatalytic and Highly Enantio- and Diastereoselective Mannich Reactions of alfa-Substituted-alfa-Cyanoacetates" Angew. Chem. Int. Ed. 2005, 44, 2896-2899

Undergraduate, Aarhus University, Karl Anker Jørgensen laboratory

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2. N. Gathergood, K. Juhl, T. B. Poulsen, K. Thordrup, K. A. Jørgensen, "Direct catalytic asymmetric aldol reactions of pyruvates: scope and mechanism" Org. Biomol. Chem. 2004, 2, 1077-1085

1. A. Bøgevig, T. B. Poulsen, W. Zhuang, K. A. Jørgensen, "Formation of Optically Active Functionalized beta-Hydroxy Nitrones Using a Proline Catalyzed Aldol Reaction of Aldehydes with Carbonyl Compounds and Nydroxylamines”, Synlett, 2003, 12, 1915-1918